Understanding how aging affects communication between mitochondria and lysosomes
Official title: Novel mitochondria-to-lysosome crosstalk contributes to lysosomal dysfunction during aging
Funded at Buck Institute for Research on Aging · NIH-10893559 · Data updated 2026-11-12
This study is looking at how two important parts of our cells, mitochondria and lysosomes, work together and how that teamwork changes as we get older, with the hope of finding ways to keep our cells healthier as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $485,000 |
| NIH project number | 5R01AG082824-02 |
| Project ID | NIH-10893559 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related cellular dysfunction or diseases associated with aging.
✕Less likely to help
Patients who are young and do not exhibit any signs of cellular aging or related diseases may not benefit from this research.
What this research studies
This research investigates the interactions between mitochondria and lysosomes, two important cellular components, and how their communication deteriorates with age. By studying these connections, the research aims to uncover the mechanisms behind age-related cellular dysfunction. The team will utilize various biological models, including human cells and the model organism C. elegans, to explore how these interactions contribute to the hallmarks of aging. The goal is to identify potential targets for interventions that could improve cellular health in aging individuals.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing cellular function and health during aging.
How similar studies have gone: Previous research has shown promising results in understanding cellular interactions in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Buck Institute for Research on Aging
Novato, United States Active
Researchers
- Principal investigator: Zhou, Chuankai — Buck Institute for Research on Aging
- Study coordinator: Zhou, Chuankai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.