Understanding how aging affects chronic diseases using mouse models
Core B - Common Mouse Models Core (CMMC)
This study is looking at how certain genes related to aging might affect health in bones, muscles, and the brain, using specially bred mice to test new treatments that could help with age-related issues.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11079492 on NIH RePORTER |
What this research studies
This research focuses on the role of specific genes, p16Ink4a and p21Cip1, in cellular aging and how they contribute to age-related diseases in various tissues. By using advanced genetic mouse models, researchers aim to investigate the effects of these genes on cellular senescence in bone, muscle, and brain tissues. The study involves breeding mice with specific genetic modifications and testing new compounds that may help target aging-related cellular changes. This approach could lead to a better understanding of aging and its impact on health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of aging and its related diseases.
Not a fit: Patients with acute conditions unrelated to aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that mitigate the effects of aging on chronic diseases.
How similar studies have performed: Previous research has shown promise in using genetic models to study aging, indicating that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Monroe, David G — Mayo Clinic Rochester
- Study coordinator: Monroe, David G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.