Understanding how aging affects cell structure and function
Single-cell analysis of 3D genome organization in senescent cells
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-11056733
This study looks at how aging affects the way our cells are organized inside, which could help us understand age-related diseases better and find new ways to treat them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11056733 on ClinicalTrials.gov |
What this research studies
This research investigates how cellular senescence, a process where cells stop dividing, impacts the organization of the genome in three-dimensional space. By analyzing individual cells, the study aims to uncover the molecular mechanisms that lead to changes in genome organization as cells age. This could help clarify whether these changes are a cause or a consequence of senescence, and how they contribute to age-related diseases. Patients may benefit from insights into how aging affects cellular function and the potential for new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or those with conditions linked to cellular senescence.
Not a fit: Patients who are young and do not have age-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of age-related diseases.
How similar studies have performed: Previous research has shown promising results in understanding cellular senescence and its implications for aging, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JAIN, RAJAN — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: JAIN, RAJAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.