Understanding how aging affects cell structure and function
Official title: Single-cell analysis of 3D genome organization in senescent cells
Funded at University of Pennsylvania · NIH-11056733 · Data updated 2026-11-12
This study looks at how aging affects the way our cells are organized inside, which could help us understand age-related diseases better and find new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $567,578 |
| NIH project number | 5R01AG082437-02 |
| Project ID | NIH-11056733 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related health issues or those with conditions linked to cellular senescence.
✕Less likely to help
Patients who are young and do not have age-related conditions may not benefit from this research.
What this research studies
This research investigates how cellular senescence, a process where cells stop dividing, impacts the organization of the genome in three-dimensional space. By analyzing individual cells, the study aims to uncover the molecular mechanisms that lead to changes in genome organization as cells age. This could help clarify whether these changes are a cause or a consequence of senescence, and how they contribute to age-related diseases. Patients may benefit from insights into how aging affects cellular function and the potential for new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of age-related diseases.
How similar studies have gone: Previous research has shown promising results in understanding cellular senescence and its implications for aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Jain, Rajan — University of Pennsylvania
- Study coordinator: Jain, Rajan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.