Understanding how aging affects cell organelles and amino acid balance
Endolysosomal Regulation of Amino Acid Homeostasis in Aging
['FUNDING_R01'] · UNIVERSITY OF UTAH · NIH-11061855
This study looks at how our cells change as we get older, especially focusing on a part of the cell called the lysosome that helps break down proteins, and how problems with it might affect other parts of the cell and our overall health as we age.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-11061855 on ClinicalTrials.gov |
What this research studies
This research investigates the deterioration of organelles in cells as we age, focusing on how this impacts amino acid homeostasis. The team studies the lysosome, an organelle crucial for protein degradation and metabolite storage, to understand its role in cellular health during aging. By using yeast as a model, they explore how lysosomal dysfunction affects other organelles, particularly mitochondria, and how this relationship influences overall cell function. The goal is to uncover mechanisms that could lead to better understanding and treatment of age-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or those at risk for age-related diseases.
Not a fit: Patients who are not experiencing age-related conditions or are significantly younger may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases by improving cellular function.
How similar studies have performed: Previous research has shown promising results in understanding organelle function in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUGHES, ADAM — UNIVERSITY OF UTAH
- Study coordinator: HUGHES, ADAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder, age dependent disease, age dependent disorder