Understanding how aging affects brain inflammation in Alzheimer's disease
Age-related repetitive element dysregulation, neuroinflammation and Alzheimer's disease
This work explores how certain genetic elements, called repetitive elements, might increase with age and cause brain inflammation, contributing to Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-11089493 on NIH RePORTER |
What this research studies
We are looking into how repetitive elements, which are parts of our genetic code, become more active as we get older. These active elements can create molecules that trigger inflammation in the brain, a process strongly linked to Alzheimer's disease. Our goal is to understand if this age-related increase in repetitive elements and the resulting inflammation are key drivers of the disease. We believe that by understanding this connection, we can find new ways to help people with Alzheimer's.
Who could benefit from this research
Good fit: This foundational work is relevant for adults, especially those aged 21 and older, who are interested in the underlying causes of Alzheimer's disease and age-related brain changes.
Not a fit: Patients seeking immediate clinical treatment or direct participation in a drug trial would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat Alzheimer's disease by targeting age-related brain inflammation.
How similar studies have performed: While the link between repetitive elements and Alzheimer's is an emerging area, previous research has shown connections between aging, inflammation, and the disease.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Larocca, Thomas — Colorado State University
- Study coordinator: Larocca, Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.