Understanding how aging affects brain immune cells in Alzheimer's disease
Dissecting the impact of senescence on microglia function and neurodegeneration
This study is looking at how aging affects brain immune cells called microglia and how their decline in function might contribute to Alzheimer's disease, with the goal of finding new ways to help keep our brains healthy as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10875736 on NIH RePORTER |
What this research studies
This research investigates the role of cellular aging, or senescence, in the function of microglia, which are immune cells in the brain. It aims to understand how senescent microglia contribute to neurodegeneration, particularly in Alzheimer's disease. The researchers will use genetic tools and animal models to explore how aging impacts the ability of these cells to clear harmful substances and how this dysfunction may lead to increased inflammation and disease progression. By examining these mechanisms, the study seeks to uncover potential therapeutic targets for improving brain health in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease, particularly older adults experiencing cognitive decline.
Not a fit: Patients with neurodegenerative conditions other than Alzheimer's disease may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance microglial function and slow down the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown that targeting cellular senescence can have protective effects in neurodegenerative models, indicating a promising avenue for further exploration.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Schafer, Dorothy Patricia — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Schafer, Dorothy Patricia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.