NIH-funded research R01 grant

Understanding how aging affects brain function, walking, and thinking skills

Official title: Trajectories and modifiable risk factors of brain, gait, and cognitive decline in aging and pre-dementia

Funded at Albert Einstein College of Medicine · NIH-11052249 · Data updated 2026-11-12

This study is looking at how getting older affects your brain health, walking, and thinking skills, especially for those who might be starting to have some memory or thinking challenges, to find ways to help improve your quality of life as you age.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionAlbert Einstein College of Medicine
NIH-funded
Lab location1 site (Bronx, United States)
Project startJune 15, 2020
Project endMarch 31, 2026
Funding year2024
Award (this year)$101,613
NIH project number3R01AG062659-05S1
Project IDNIH-11052249 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are older adults, particularly those who are cognitively healthy or in the early stages of cognitive decline.

Less likely to help

Patients with advanced dementia or severe mobility impairments may not benefit from this research.

What this research studies

This research investigates how aging impacts brain health, walking ability, and cognitive function in older adults. It focuses on identifying the changes in brain structure and function that may lead to difficulties in walking and thinking, particularly in those who are starting to experience cognitive decline. By analyzing these changes, the research aims to uncover modifiable risk factors that could help improve the quality of life for older adults. Participants will be monitored over time to track their brain health and walking patterns, providing valuable insights into the aging process.

Why it matters

Potential benefit: If successful, this research could lead to strategies that help prevent or slow down cognitive decline and improve mobility in older adults.

How similar studies have gone: Previous research has shown promising results in understanding the relationship between gait and cognitive decline, indicating that this approach has potential for success.

Where this research is happening

  • Albert Einstein College of Medicine
    Bronx, United States
    Active

Researchers

  • Principal investigator: Blumen, Helena M — Albert Einstein College of Medicine
  • Study coordinator: Blumen, Helena M

Related research

Other NIH-funded projects on the same topics.

  • Understanding how aging affects brain function, walking, and thinking skills

    This study looks at how getting older affects your brain health, walking, and thinking skills, especially for older adults who might be starting to have some memory issues, to find ways to help improve their quality of life and prevent falls and dementia.

    NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-10808994

  • Peripheral immune signals and blood vessel health in aging and dementia

    This project looks at how platelet and neutrophil activity relate to brain changes and biomarkers of Alzheimer’s disease in older adults, especially those at higher cardiovascular risk.

    NIH research New York University School of Medicine · New York, United States · NIH-11413466

  • BA-UMAP: Understanding cognitive aging in Black adults using remote assessments

    A large US study follows 600 Black adults aged 55+ over several years to understand how biopsychosocial factors relate to cognitive change, using online surveys, remote cognitive tests, and optional saliva/urine samples.

    NIH research North Carolina Agri & Tech St Univ · Greensboro, United States · NIH-11375515

  • Midlife memory and dementia risk in Kenyan adults

    This work looks at midlife thinking and memory and how childhood health and life experiences might affect future dementia risk for Kenyan adults.

    NIH research University of California Berkeley · Berkeley, United States · NIH-11322043

  • Understanding Memory and Aging in Black Adults

    This effort aims to learn more about why Alzheimer's disease and related memory problems are more common in Black adults by looking at various health and social factors.

    NIH research North Carolina Agri & Tech St Univ · Greensboro, United States · NIH-11178671

  • Investigating risk factors for Alzheimer's disease and related dementias in Kenyan adults.

    This study is looking at what might increase the chances of developing Alzheimer's and related dementias in Kenyan adults aged 35 to 43, by exploring how their health, education, and social attitudes have changed since childhood.

    NIH research University of California Berkeley · Berkeley, United States · NIH-11082349

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.