Understanding how aging affects brain cells that support nerve function
Cell-intrinsic and contextual determinants of aging by human glial progenitor cells
['FUNDING_R01'] · UNIVERSITY OF ROCHESTER · NIH-10868609
This study is looking at how getting older affects special brain cells that help repair and support our brain, and it's for anyone interested in understanding how we can keep our brains healthy as we age.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10868609 on ClinicalTrials.gov |
What this research studies
This research investigates how aging impacts glial progenitor cells (GPCs) in the human brain, which are crucial for producing new supportive cells in response to damage. The team aims to uncover the genetic and epigenetic factors that hinder these cells from functioning effectively as we age. By analyzing these factors, the researchers hope to find ways to enhance the ability of GPCs to regenerate and maintain healthy brain function, particularly in age-related and inflammatory conditions. This work involves both laboratory studies and in vivo experiments to ensure findings are applicable to human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may be experiencing age-related cognitive decline or neuroinflammatory conditions.
Not a fit: Patients with acute neurological injuries or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance brain cell regeneration and prevent cognitive decline associated with aging.
How similar studies have performed: While the approach of targeting glial progenitor cells is innovative, similar studies have shown promise in understanding cell aging and regeneration in other contexts.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOLDMAN, STEVEN ALAN — UNIVERSITY OF ROCHESTER
- Study coordinator: GOLDMAN, STEVEN ALAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.