Understanding how aging affects brain cells in Alzheimer's disease
Mapping Cellular Resolution Connectopathies in Aging and Alzheimer's Disease
This study is looking at how brain cells change as we get older and how those changes relate to Alzheimer's disease, with the hope that understanding these differences can help develop new treatments for people affected by memory and navigation issues.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11085074 on NIH RePORTER |
What this research studies
This research investigates the specific changes in brain cells associated with aging and Alzheimer's disease, focusing on the entorhinal cortex, a critical area for memory and navigation. By using advanced techniques like single-nucleus RNA sequencing, the study aims to map the molecular and anatomical characteristics of different types of neurons as they age and in the presence of Alzheimer's pathology. The research will involve both animal models and humanized models to provide insights into how these changes contribute to cognitive decline. Patients may benefit from the findings, which could lead to new therapeutic strategies targeting these cellular changes.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or those diagnosed with Alzheimer's disease.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent cognitive decline in aging individuals and those with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding cellular changes in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Dong, Hong-Wei — University of California Los Angeles
- Study coordinator: Dong, Hong-Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.