Understanding how aging affects brain cells and memory in Alzheimer's disease
Official title: Metabolic determinants of reactive astrogliosis and cognitive heterogeneity in aging
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-11190805 · Data updated 2026-11-12
This study is looking at how aging affects memory and thinking in people with Alzheimer's and similar conditions, focusing on a special type of brain cell called astrocytes, to find ways to help improve brain health as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | September 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $434,218 |
| NIH project number | 5R01AG085398-02 |
| Project ID | NIH-11190805 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing cognitive decline or those at risk for Alzheimer's disease.
✕Less likely to help
Patients with early-stage Alzheimer's disease or those with significant cognitive impairment may not benefit from this research.
What this research studies
This research investigates the relationship between aging and cognitive decline in Alzheimer's disease and related dementias. It focuses on the role of astrocytes, a type of brain cell, and their mitochondrial function in cognitive impairment. By using advanced testing methods, the study aims to identify different cognitive performance levels in aged subjects, which could help in understanding the mechanisms behind memory decline. The findings may lead to new therapeutic strategies targeting astrocyte function to improve cognitive health in aging populations.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function in older adults at risk for Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of astrocytes in cognitive function, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Logan, Sreemathi — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Logan, Sreemathi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.