Understanding how aging affects brain cell connections in Alzheimer's disease
Investigating the Neuronal Signals Initiating Synapse Loss in Aging and Alzheimer's Disease
This study is looking at how aging affects brain connections in people with Alzheimer's disease, using older monkeys to find out what signals cause these important connections to break down, with the hope of discovering new ways to help improve brain health as we get older.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10906957 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind synapse loss in the brain as people age, particularly in relation to Alzheimer's disease. Using aged rhesus macaques, the study aims to identify the neuronal signals that lead to the removal of synapses, which are crucial for cognitive function. The researchers will explore how certain molecules, triggered by aging, may contribute to this synapse loss and cognitive decline. By understanding these processes, the research hopes to uncover potential targets for future therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or those diagnosed with Alzheimer's disease.
Not a fit: Patients with early-stage Alzheimer's or those without cognitive impairment may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing cognitive decline in aging individuals and those with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding synapse loss in animal models, indicating that this approach may yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Woo, Elizabeth Ka-Yoon — Yale University
- Study coordinator: Woo, Elizabeth Ka-Yoon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.