Understanding how aging affects brain cell connections
Neuronal Circuit Maintenance in Healthy Aging
This study is looking at how our brain cells stay healthy as we get older and whether turning on certain genes can help improve their function, which could be helpful for anyone concerned about memory and thinking as they age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11011463 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that help maintain neuronal function as people age. It focuses on how changes in neuronal activity influence the properties of aging neurons and whether re-engaging specific gene regulators can improve neuronal function. The study examines the role of a transcription factor called NPAS4, which is involved in gene expression related to neuronal activity and may help repair damage in aging brains. By exploring these cellular and molecular processes, the research aims to uncover potential strategies to combat age-related cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing age-related cognitive changes or are at risk for neurodegenerative diseases.
Not a fit: Patients with acute neurodegenerative diseases or severe cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that preserve cognitive function and prevent neurodegenerative diseases in older adults.
How similar studies have performed: Other research has shown promise in understanding neuronal function and aging, but this specific approach focusing on NPAS4 is relatively novel.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Pollina, Elizabeth a — Washington University
- Study coordinator: Pollina, Elizabeth a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.