Understanding how aging affects bone health
Project 1 - Cellular Senescence and Bone Aging
This study is looking at how certain proteins related to aging affect bone health, especially in older adults, to help find new ways to keep bones strong as we age.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11079509 on NIH RePORTER |
What this research studies
This research investigates the biological processes that contribute to bone aging, particularly focusing on two proteins, p16Ink4a and p21Cip1, which are linked to cellular senescence. By studying these proteins in various tissues, the research aims to uncover how they influence the aging process and lead to bone loss. The approach includes advanced techniques like single-cell proteomics and RNA sequencing to analyze the behavior of senescent cells in bones, muscles, and the brain. This comprehensive understanding could pave the way for new treatments to improve bone health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may be experiencing age-related bone loss.
Not a fit: Patients under the age of 65 or those without signs of age-related bone issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that prevent or reverse age-related bone loss, enhancing the quality of life for older adults.
How similar studies have performed: Previous research has shown promising results in understanding cellular senescence and its impact on aging, suggesting that this approach could yield significant insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Khosla, Sundeep — Mayo Clinic Rochester
- Study coordinator: Khosla, Sundeep
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.