Understanding how aging affects bone fracture healing
Official title: Cell senescence in aging fracture
Funded at University of Rochester · NIH-10981892 · Data updated 2026-11-12
This study is looking at how certain aging cells affect the healing of bone fractures in older adults and is exploring new treatments that could help improve recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $548,212 |
| NIH project number | 1R01AG084707-01A1 |
| Project ID | NIH-10981892 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly individuals who have experienced bone fractures and may be suffering from age-related conditions like osteoporosis.
✕Less likely to help
Patients who are not elderly or those without bone fractures may not benefit from this research.
What this research studies
This research investigates the role of cellular senescence in the healing process of bone fractures in elderly patients. It focuses on understanding how certain senescent cells can hinder recovery and how new therapies, including senolytic drugs, may improve healing outcomes. By using advanced techniques like single-cell RNA sequencing, the study aims to identify specific cell types involved in fracture repair and their effects on healing in older adults. The ultimate goal is to develop targeted treatments that enhance recovery from fractures in aging populations.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that significantly enhance fracture healing in elderly patients, reducing recovery time and associated health risks.
How similar studies have gone: Previous research has shown promising results in using senolytic drugs to improve healing in aged models, indicating potential for success in this approach.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Zhang, Hengwei — University of Rochester
- Study coordinator: Zhang, Hengwei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.