Understanding how aging affects bone cells in osteoarthritis
Senescence of Pre-Osteoclasts in Non-Traumatic OA
This study is looking at how aging cells in the bone might play a role in developing osteoarthritis, especially in older adults, to help find new ways to treat this common joint problem.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11004729 on NIH RePORTER |
What this research studies
This research investigates the role of cellular aging in the development of non-traumatic osteoarthritis (OA), a common joint disease associated with aging. The study focuses on the accumulation of senescent pre-osteoclasts in the bone marrow and how these cells contribute to the progression of OA. By examining both spontaneous aging mice and those with metabolic dysregulation, the researchers aim to uncover unique features of non-traumatic OA that differ from post-traumatic cases. The findings could lead to new insights into the mechanisms of OA and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing symptoms of non-traumatic osteoarthritis.
Not a fit: Patients with post-traumatic osteoarthritis or those without joint issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of osteoarthritis in older adults.
How similar studies have performed: Previous research has shown that targeting cellular senescence can be beneficial in other age-related conditions, suggesting potential success for this approach in osteoarthritis.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Wan, Mei — Johns Hopkins University
- Study coordinator: Wan, Mei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.