Understanding how aging affects blood vessel function and cognitive decline
Age-related vascular cognitive impairment: role of endothelial senescence
This study looks at how getting older affects the blood vessels in the brain and how that might relate to memory and thinking problems in people aged 65 and up, with the goal of finding ways to help improve blood flow and brain function as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10912603 on NIH RePORTER |
What this research studies
This research investigates the impact of aging on blood vessel function in the brain and its relationship to cognitive decline in individuals aged 65 and older. The study focuses on how the aging process leads to changes in endothelial cells, which are crucial for maintaining healthy blood flow and brain function. By examining the mechanisms behind endothelial senescence and its effects on neurovascular coupling and inflammation, the research aims to identify potential therapies that could improve blood flow and cognitive abilities in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing cognitive decline or have been diagnosed with vascular cognitive impairment.
Not a fit: Patients under the age of 65 or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cognitive function and quality of life for older adults experiencing vascular cognitive impairment.
How similar studies have performed: While the specific approach of this research is novel, there is growing evidence from other studies that targeting endothelial function can improve cognitive outcomes in older adults.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Csiszar, Anna — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Csiszar, Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.