Understanding how aging affects blood stem cells and their ability to regenerate blood and immune cells.
Official title: Translation Fidelity in Hematopoietic Stem Cell Aging and Longevity
Funded at University of California, San Diego · NIH-10943031 · Data updated 2026-11-12
This study looks at how getting older affects the blood-making stem cells in our bodies and whether making these cells better at producing proteins can help them work longer and better, which could lead to new treatments for blood disorders that come with age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $651,793 |
| NIH project number | 1R01AG088725-01 |
| Project ID | NIH-10943031 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults experiencing blood-related health issues such as anemia or immune dysfunction.
✕Less likely to help
Patients with acute blood disorders unrelated to aging or those who are not experiencing any blood-related health issues may not benefit from this research.
What this research studies
This research investigates how aging impacts hematopoietic stem cells (HSCs), which are crucial for producing blood and immune cells. It focuses on the concept of translation fidelity, which refers to the accuracy of protein synthesis in these cells. By comparing young and old HSCs, the study aims to determine if enhancing translation fidelity can improve the function and longevity of aging stem cells. Patients may benefit from insights that could lead to new treatments for age-related blood disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for age-related blood disorders, enhancing the health and longevity of older adults.
How similar studies have gone: While the specific approach of studying translation fidelity in HSCs is novel, related research has shown that enhancing cellular functions can improve outcomes in aging populations.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Signer, Robert A.j. — University of California, San Diego
- Study coordinator: Signer, Robert A.j.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.