Understanding how aging affects blood stem cells
Protein homeostasis in hematopoietic stem cells
This study is looking at how getting older affects the blood and immune cells in our bodies, focusing on how proteins can get messed up in the stem cells that make these cells, and it aims to find ways to help older adults produce healthier blood cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11097255 on NIH RePORTER |
What this research studies
This research investigates how aging impacts hematopoietic stem cells (HSCs), which are responsible for producing blood and immune cells. The study focuses on the role of protein homeostasis, or proteostasis, in maintaining the health and function of these stem cells as they age. Researchers will explore how misfolded proteins accumulate in HSCs and how this affects their ability to regenerate blood cells. By examining the mechanisms behind HSC aging, the research aims to identify potential strategies to enhance blood cell production in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who may be experiencing age-related declines in blood cell production or related health issues.
Not a fit: Patients who are younger than 21 or do not have any age-related blood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for age-related blood disorders and enhance the overall health of older adults.
How similar studies have performed: Previous research has shown that addressing proteostasis can improve cell function in other contexts, suggesting potential for success in this area as well.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Signer, Robert A.j. — University of California, San Diego
- Study coordinator: Signer, Robert A.j.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.