Understanding how aging affects blood cell mutations and inflammation
uNDERSTANDING AND TARGETING SENESCENCE IN CLONAL HEMATOPOIESIS
This study is looking at how certain changes in blood stem cells can lead to more blood cells and create inflammation, and it's aimed at finding new treatments to help older patients who might be affected by this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project ID | NIH-11232015 on NIH RePORTER |
What this research studies
This research investigates clonal hematopoiesis, a condition where mutations in blood stem cells lead to an increase in certain blood cells without causing disease. The study aims to understand how these mutated cells create an inflammatory environment that promotes their own growth and survival. By using advanced techniques like CRISPR/Cas9 screening, researchers will identify specific inflammatory signals that could be targeted for new therapies. This approach seeks to develop treatments that specifically address the harmful effects of these mutations, particularly in older patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have been diagnosed with clonal hematopoiesis or are at risk for hematological malignancies.
Not a fit: Patients without clonal hematopoiesis or those who are younger and not at risk for related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce the risk of blood cancers and other serious health issues associated with clonal hematopoiesis.
How similar studies have performed: Previous research has shown promising results in targeting inflammation in similar conditions, suggesting that this approach may be effective.
Where this research is happening
Cold Spring Harbor, United States
- Cold Spring Harbor Laboratory — Cold Spring Harbor, United States (Active)
Researchers
- Principal investigator: Fernandez Maestre, Ines — Cold Spring Harbor Laboratory
- Study coordinator: Fernandez Maestre, Ines
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.