Understanding how aging affects blood cell mutations and inflammation
Official title: uNDERSTANDING AND TARGETING SENESCENCE IN CLONAL HEMATOPOIESIS
Funded at Cold Spring Harbor Laboratory · NIH-11232015 · Data updated 2026-11-12
This study is looking at how certain changes in blood stem cells can lead to more blood cells and create inflammation, and it's aimed at finding new treatments to help older patients who might be affected by this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $101,491 |
| NIH project number | 4K00CA284253-03 |
| Project ID | NIH-11232015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who have been diagnosed with clonal hematopoiesis or are at risk for hematological malignancies.
✕Less likely to help
Patients without clonal hematopoiesis or those who are younger and not at risk for related conditions may not benefit from this research.
What this research studies
This research investigates clonal hematopoiesis, a condition where mutations in blood stem cells lead to an increase in certain blood cells without causing disease. The study aims to understand how these mutated cells create an inflammatory environment that promotes their own growth and survival. By using advanced techniques like CRISPR/Cas9 screening, researchers will identify specific inflammatory signals that could be targeted for new therapies. This approach seeks to develop treatments that specifically address the harmful effects of these mutations, particularly in older patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce the risk of blood cancers and other serious health issues associated with clonal hematopoiesis.
How similar studies have gone: Previous research has shown promising results in targeting inflammation in similar conditions, suggesting that this approach may be effective.
Where this research is happening
-
Cold Spring Harbor Laboratory
Cold Spring Harbor, United States Active
Researchers
- Principal investigator: Fernandez Maestre, Ines — Cold Spring Harbor Laboratory
- Study coordinator: Fernandez Maestre, Ines
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.