Understanding how aging affects blood cell mutations and disease risk
Targeting Clonal Hematopoiesis of Indeterminate Potential using Human Genetics
This study is looking at how getting older can cause changes in blood stem cells that might lead to health issues like cancer and heart problems, and it’s for anyone interested in understanding how these changes happen and what we can do to prevent them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10912669 on NIH RePORTER |
What this research studies
This research investigates how aging leads to mutations in blood stem cells, a condition known as Clonal Hematopoiesis of Indeterminate Potential (CHIP). By analyzing genetic data from over 800,000 individuals, the study aims to uncover the genetic factors that contribute to the development and expansion of CHIP, as well as its association with diseases like cancer and cardiovascular issues. The research includes laboratory experiments to understand how these genetic variations affect blood cell function. Ultimately, the goal is to identify potential therapeutic targets to prevent CHIP and its related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may be at risk for age-related diseases linked to blood cell mutations.
Not a fit: Patients who are under 21 years old or do not have any risk factors for age-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or mitigate diseases associated with aging.
How similar studies have performed: Other research has shown promise in understanding genetic factors related to aging and blood disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Bick, Alexander — Vanderbilt University Medical Center
- Study coordinator: Bick, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.