Understanding how aging affects blood cell development and disease risk
Mechanisms of marrow microenvironmental aging and their impact of progression of clonal hematopoiesis
This study is looking at how aging affects certain mutated blood cells that can raise the risk of blood cancers, and it aims to find ways to improve prevention and treatment, so if you're interested in how your blood health and genetics relate to aging, this research might be for you!
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11058393 on NIH RePORTER |
What this research studies
This research investigates how the aging microenvironment influences the behavior of mutated blood cells, known as clonal hematopoiesis, which can increase the risk of blood cancers and other health issues. By studying the interactions between aging and these mutated cells, the researchers aim to uncover mechanisms that could lead to better prevention and treatment strategies. The approach includes examining the role of specific proteins that regulate DNA stability and inflammation, as well as testing existing medications that may mitigate the effects of aging on blood cell health. Patients may be involved in studies that assess their blood health and genetic factors related to aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who may have clonal hematopoiesis or are at risk for blood-related diseases.
Not a fit: Patients who are younger and do not have any signs of clonal hematopoiesis or related blood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing blood cancers and enhancing overall health in older adults.
How similar studies have performed: Previous research has shown that targeting the aging microenvironment can yield promising results in improving health outcomes, suggesting that this approach may be effective.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Calvi, Laura M — University of Rochester
- Study coordinator: Calvi, Laura M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.