Understanding how aging affects blood cell development and disease risk
Official title: Determinants of Myeloid Clonal Evolution
Funded at Johns Hopkins University · NIH-10994134 · Data updated 2026-11-12
This study is looking at how getting older affects our blood cells and the chance of developing blood disorders, especially focusing on a genetic marker that might help protect against blood cancers, and it’s particularly aimed at understanding this in African American women.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 5, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $171,720 |
| NIH project number | 5K08HL163468-03 |
| Project ID | NIH-10994134 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old, particularly those with a family history of blood disorders or who are of African American descent.
✕Less likely to help
Patients with no history of blood disorders or those under 21 years old may not benefit from this research.
What this research studies
This research investigates how aging influences the development of blood cells and the risk of blood disorders. It focuses on the role of telomere length, a genetic marker, in the evolution of clonal hematopoiesis, which can lead to conditions like myelodysplastic and myeloproliferative disorders. The study will analyze data from a diverse group of participants, particularly African American women, to identify genetic mutations that may protect against blood cancers. By understanding these mechanisms, the research aims to improve early detection and prevention strategies for blood-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of blood disorders associated with aging.
How similar studies have gone: Previous research has shown promising results in understanding clonal hematopoiesis and its implications for blood disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Schratz, Kristen E — Johns Hopkins University
- Study coordinator: Schratz, Kristen E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.