Understanding how aging affects B-cells in people living with HIV
Official title: Mucosal B-cell aging in PLWH
Funded at University of California Los Angeles · NIH-11170833 · Data updated 2026-11-12
This study is looking at how aging affects the immune system, specifically B-cells, in people living with HIV, to understand how these changes might make it harder for their bodies to fight infections and respond to vaccines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 26, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $392,709 |
| NIH project number | 1R56AG086059-01 |
| Project ID | NIH-11170833 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults living with HIV who are receiving antiretroviral therapy.
✕Less likely to help
Patients who are not living with HIV or who are younger and not experiencing age-related immune decline may not benefit from this research.
What this research studies
This research investigates the effects of aging on B-cells in individuals living with HIV, particularly focusing on how these changes impact immune responses. It aims to explore the relationship between HIV infection and accelerated aging, especially in the context of humoral immunity, which is crucial for fighting infections. By studying gut-associated lymphoid tissue, the research seeks to uncover how aging influences the immune system's ability to respond to pathogens and vaccines. This could provide insights into the mechanisms behind immune dysfunction in older adults with HIV.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses in older individuals living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding immune aging in other chronic conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Epeldegui, Marta — University of California Los Angeles
- Study coordinator: Epeldegui, Marta
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.