Understanding how aging affects B-cells in people living with HIV
Mucosal B-cell aging in PLWH
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11170833
This study is looking at how aging affects the immune system, specifically B-cells, in people living with HIV, to understand how these changes might make it harder for their bodies to fight infections and respond to vaccines.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11170833 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of aging on B-cells in individuals living with HIV, particularly focusing on how these changes impact immune responses. It aims to explore the relationship between HIV infection and accelerated aging, especially in the context of humoral immunity, which is crucial for fighting infections. By studying gut-associated lymphoid tissue, the research seeks to uncover how aging influences the immune system's ability to respond to pathogens and vaccines. This could provide insights into the mechanisms behind immune dysfunction in older adults with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults living with HIV who are receiving antiretroviral therapy.
Not a fit: Patients who are not living with HIV or who are younger and not experiencing age-related immune decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses in older individuals living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding immune aging in other chronic conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EPELDEGUI, MARTA — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: EPELDEGUI, MARTA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus