Understanding how aging affects arteries through immune cells
Official title: Mechanisms of CD8+ mediated cell non-autonomous arterial aging
Funded at University of Texas Arlington · NIH-11065504 · Data updated 2026-11-12
This study looks at how certain immune cells called CD8+ T cells affect the aging of arteries, which can lead to stiffness and poor blood flow, and it aims to help people understand how these immune responses might impact heart health as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Arlington NIH-funded |
| Lab location | 1 site (Arlington, United States) |
| Project start | April 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $535,902 |
| NIH project number | 5R01AG086447-02 |
| Project ID | NIH-11065504 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old, particularly those experiencing age-related cardiovascular issues.
✕Less likely to help
Patients with acute cardiovascular conditions unrelated to aging may not benefit from this research.
What this research studies
This research investigates the role of CD8+ T cells in the aging process of arteries, focusing on how these immune cells contribute to arterial stiffness and impaired blood flow. By examining the mechanisms behind T cell accumulation and their effects on arterial cells, the study aims to uncover the cellular interactions that lead to age-related cardiovascular issues. Patients may benefit from insights into how immune responses influence vascular health as they age, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve vascular health and reduce the risk of cardiovascular diseases in older adults.
How similar studies have gone: Other research has shown promising results in understanding the role of immune cells in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Arlington
Arlington, United States Active
Researchers
- Principal investigator: Trott, Daniel — University of Texas Arlington
- Study coordinator: Trott, Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.