Understanding how age-related macular degeneration affects cell metabolism
Official title: Metabolism of AMD iPSC-derived RPE
Funded at University of Washington · NIH-10925253 · Data updated 2026-11-12
This study is looking at how certain eye cells from people with age-related macular degeneration (AMD) use nutrients and change over time, with the hope of finding new ways to treat this condition and help prevent vision loss.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 30, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $416,628 |
| NIH project number | 5U01EY034591-03 |
| Project ID | NIH-10925253 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who are affected by age-related macular degeneration.
✕Less likely to help
Patients under the age of 65 or those without age-related macular degeneration may not benefit from this research.
What this research studies
This research investigates the metabolism of retinal pigment epithelium (RPE) cells derived from induced pluripotent stem cells (iPSCs) of patients with age-related macular degeneration (AMD). By studying these cells in a controlled laboratory setting, researchers aim to identify the metabolic changes that occur in AMD, including how nutrients and metabolites affect cell function. The project seeks to improve the understanding of disease mechanisms and develop potential therapeutic targets for AMD. Patients may benefit from insights gained that could lead to new treatments for this common cause of blindness.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating age-related macular degeneration.
How similar studies have gone: Previous research using iPSC-derived models has shown promise in understanding AMD, indicating that this approach has potential for success.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Chao, Jennifer Rayming — University of Washington
- Study coordinator: Chao, Jennifer Rayming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.