Understanding how age and sex affect HIV treatment outcomes
Quantifying Sex-and-Age-Related Differences in Antiretroviral Exposure and Adverse Effects in the MACS/WIHS Combined Cohort Study
This study is looking at how things like age and gender affect how well HIV medications work and their side effects, especially weight gain, so we can better understand which groups of people might need special care when taking these drugs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11059854 on NIH RePORTER |
What this research studies
This research investigates how different factors such as age and sex influence the effectiveness and side effects of HIV medications in a diverse group of people living with HIV. By analyzing data from a large cohort, the study aims to identify specific patient subgroups that may be at higher risk for adverse effects, particularly weight gain, from antiretroviral drugs. The research will utilize advanced modeling techniques to assess drug exposure and its variability among participants, ultimately aiming to provide tailored recommendations for minimizing negative health impacts. Patients will be enrolled from multiple sites to ensure a broad representation of demographics and health backgrounds.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV, particularly those who are diverse in age and sex, including African American women.
Not a fit: Patients who are not living with HIV or those who do not fall within the age and demographic focus of the study may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies that reduce adverse effects of HIV medications, improving overall health outcomes for patients.
How similar studies have performed: Previous research has shown success in understanding pharmacokinetics and adverse effects in HIV treatment, making this approach both relevant and promising.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Dumond, Julie Brumer — Univ of North Carolina Chapel Hill
- Study coordinator: Dumond, Julie Brumer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.