Understanding how age affects vaccine responses to pneumonia
The role of neutrophils in the age-driven decline in anti-pneumococcal vaccine responses
This study is looking at how certain immune cells in older adults affect how well the pneumococcal vaccine works, with the goal of finding better ways to protect seniors from infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-11105930 on NIH RePORTER |
What this research studies
This research investigates how neutrophils, a type of immune cell, contribute to the decline in effectiveness of the pneumococcal vaccine in older adults. The study aims to uncover the mechanisms behind immune system changes in aging that lead to reduced vaccine responses. By examining the role of these immune cells in both young and elderly populations, the researchers hope to identify why older individuals are more susceptible to infections despite vaccination. The findings could lead to improved vaccination strategies for the elderly.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are receiving or have received the pneumococcal vaccine.
Not a fit: Patients younger than 65 or those who have not received the pneumococcal vaccine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance vaccine efficacy in older adults, reducing their risk of pneumonia and related complications.
How similar studies have performed: Previous research has indicated that immune responses decline with age, but this specific investigation into neutrophils and vaccine efficacy in older adults is novel.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Bou Ghanem, Elsa — State University of New York at Buffalo
- Study coordinator: Bou Ghanem, Elsa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.