Understanding how age affects immune responses after brain injuries
Divergent age-dependent peripheral innate immune response following TBI
This study is looking at how the immune system reacts to brain injuries differently in younger and older people, focusing on certain immune cells, to help find better treatments for recovery based on age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project ID | NIH-10875398 on NIH RePORTER |
What this research studies
This research investigates how the immune response to traumatic brain injury (TBI) varies with age, focusing on the role of specific immune cells called peripheral-derived monocytes/macrophages. The study aims to uncover the cellular and molecular mechanisms that lead to different outcomes in younger versus older individuals following brain trauma. By using advanced techniques, including genetic models and behavioral assessments, the researchers will explore how these immune responses contribute to brain recovery and dysfunction. The findings could help identify new therapeutic strategies tailored to different age groups.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 21 and younger who have experienced a traumatic brain injury.
Not a fit: Patients over the age of 21 or those without a history of traumatic brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for brain injuries that take age-related immune responses into account.
How similar studies have performed: Previous studies have shown that age can significantly influence immune responses in various conditions, suggesting that this research could build on established findings.
Where this research is happening
Blacksburg, United States
- Virginia Polytechnic Inst and St Univ — Blacksburg, United States (Active)
Researchers
- Principal investigator: Theus, Michelle Lee — Virginia Polytechnic Inst and St Univ
- Study coordinator: Theus, Michelle Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.