Understanding how age affects heart drug responses
Official title: Investigating age-dependent differences in cardiac drug response
Funded at Children's Research Institute · NIH-10996912 · Data updated 2026-11-12
This study is looking at how the age of kids with heart problems affects how well their hearts respond to certain heart medications, using young guinea pigs to help find better treatments for children after heart surgery.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $35,398 |
| NIH project number | 1F31HL172563-01A1 |
| Project ID | NIH-10996912 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pediatric patients with congenital heart disease who require pharmacological interventions post-surgery.
✕Less likely to help
Patients without congenital heart disease or those who are not in the pediatric age group may not benefit from this research.
What this research studies
This research investigates how the age of pediatric patients with congenital heart disease influences their response to cardiac medications. By using a juvenile guinea pig model, the study will measure various cardiac functions and responses to drugs like calcium, dopamine, and milrinone. The goal is to understand the differences in drug effectiveness based on the maturity of heart cells, which could lead to more tailored and effective treatments for children after heart surgery.
Why it matters
Potential benefit: If successful, this research could lead to improved drug therapies specifically designed for pediatric patients, enhancing their recovery and overall cardiac health.
How similar studies have gone: While there has been limited research specifically targeting age-dependent drug responses in pediatric cardiac patients, similar studies in other areas have shown promising results in tailoring treatments based on developmental stages.
Where this research is happening
-
Children's Research Institute
Washington, United States Active
Researchers
- Principal investigator: Salameh, Shatha — Children's Research Institute
- Study coordinator: Salameh, Shatha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.