Understanding how age affects cognitive function in patients after stem cell and CAR-T treatments
Exploring Age Differences in Patient Reported Cognitive Function Trajectories among Hematopoietic Stem Cell Transplant and Chimeric Antigen Receptor T-cell patients and Linking Two Key Measures
This study is looking at how memory and thinking skills change over time for people who have had stem cell or CAR-T therapy, especially focusing on how these changes might be different for younger and older patients, and it will use feedback from patients to understand their experiences better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10593018 on NIH RePORTER |
What this research studies
This research investigates the cognitive function trajectories of patients who have undergone hematopoietic stem cell transplantation (HCT) and Chimeric Antigen Receptor T-cell (CAR-T) therapy, focusing on how these trajectories differ by age. It emphasizes the importance of patient-reported outcomes (PROs), which capture patients' own assessments of their symptoms and functioning. By utilizing a large clinical registry, the study aims to gather more representative data on cognitive dysfunction, particularly among older and diverse patient populations. The research will employ the Patient-Reported Outcomes Measurement Information System (PROMIS) to assess cognitive function and its variations across different age groups.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who have received HCT or CAR-T therapy for hematologic diseases.
Not a fit: Patients who are younger than 21 years old or those who have not undergone HCT or CAR-T therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive dysfunction in older patients undergoing HCT and CAR-T treatments.
How similar studies have performed: Previous research has shown that understanding patient-reported outcomes can significantly enhance treatment approaches, indicating potential success for this study's methodology.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Cusatis, Rachel Nicole — Medical College of Wisconsin
- Study coordinator: Cusatis, Rachel Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.