Understanding how age affects blood cell development and diseases
Control of hematopoietic maturation by Lin28b/let-7
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-11103346
This study is looking at how blood diseases differ between babies, kids, and adults by exploring how certain blood cells develop as we age, which could help find better treatments for these conditions based on age.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11103346 on ClinicalTrials.gov |
What this research studies
This research investigates the differences in blood diseases that affect infants, children, and adults, focusing on the role of hematopoietic stem and progenitor cells (HSPCs). The team aims to understand how the maturation of these cells changes with age and how this impacts the development of blood disorders. By studying the Lin28b/let-7 molecular pathway, they hope to uncover mechanisms that regulate blood cell formation and function. This could lead to insights into age-specific treatments for blood diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants, children, and adults who are affected by blood disorders.
Not a fit: Patients with blood diseases that are not influenced by age-related factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies for blood diseases that are tailored to different age groups.
How similar studies have performed: Previous research has shown promising results in understanding the role of developmental factors in blood diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROWE, ROBERT GRANT — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: ROWE, ROBERT GRANT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.