Understanding how African Green Monkeys respond to a specific bacteria that causes flea-borne spotted fever.
Susceptibility of African Green Monkeys (Chlorocebus aethiops sabaeus) to Rickettsia felis, the agent of flea-borne spotted fever
This study is looking at how African Green Monkeys react to a bacteria called Rickettsia felis, which causes a type of illness spread by fleas, to help us learn more about the disease and how it affects people, so we can find better ways to treat it.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ross University Sch/veterinary Medicine NIH-funded |
| Lab location | 1 site (Basseterre, ST KITTS/NEVIS) |
| Project ID | NIH-10606549 on NIH RePORTER |
What this research studies
This research investigates the susceptibility of African Green Monkeys to Rickettsia felis, the bacteria responsible for flea-borne spotted fever. By using these monkeys as a model, the study aims to explore the disease's pathogenesis, immune responses, and potential vectors beyond the known cat flea. The research employs advanced techniques such as PCR to analyze infections and seeks to clarify the role of Rickettsia felis in human health. This work is crucial for developing effective treatments and understanding the disease's dynamics.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals living in regions where flea-borne spotted fever is prevalent, particularly in Africa and Asia.
Not a fit: Patients who do not reside in areas affected by flea-borne spotted fever or those who are not at risk of exposure to Rickettsia felis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of flea-borne spotted fever in humans.
How similar studies have performed: While this research explores a relatively novel approach using non-human primates, similar studies have shown promise in understanding other infectious diseases.
Where this research is happening
Basseterre, ST KITTS/NEVIS
- Ross University Sch/veterinary Medicine — Basseterre, St Kitts/nevis (Active)
Researchers
- Principal investigator: Valentine, Matthew John — Ross University Sch/veterinary Medicine
- Study coordinator: Valentine, Matthew John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.