Understanding how adult pluripotent stem cells develop
The developmental origin of adult pluripotent stem cells
This study is exploring how certain animals that can regenerate parts of their bodies create special stem cells that can turn into different types of cells, helping us understand how these amazing abilities work and how they might be used in medicine.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10996921 on NIH RePORTER |
What this research studies
This research investigates the formation of adult pluripotent stem cells (aPSCs) during development, focusing on highly regenerative species. By studying these organisms, the research aims to uncover the molecular and cellular mechanisms that govern the specification and maintenance of aPSCs. The project utilizes advanced techniques such as ATAC sequencing to analyze chromatin states associated with stem cell identity. This work seeks to fill significant gaps in our understanding of how these stem cells are established and retained throughout an organism's life.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals interested in advancements in regenerative therapies and those with conditions that could be treated through stem cell applications.
Not a fit: Patients with conditions unrelated to stem cell biology or those not seeking regenerative treatments may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in regenerative medicine by enhancing our understanding of stem cell biology.
How similar studies have performed: Other research has shown success in understanding stem cell mechanisms in model organisms, suggesting that this approach has the potential for significant findings.
Where this research is happening
Cambridge, United States
- Harvard University — Cambridge, United States (Active)
Researchers
- Principal investigator: Bump, Paul Alexander Kai — Harvard University
- Study coordinator: Bump, Paul Alexander Kai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.