Understanding how adrenal stress response can protect against harmful immune reactions during cancer treatment
Official title: Mechanism of the adrenal stress response protection against therapy-induced lethal immune activation
Funded at VA Medical Center - Lexington, Ky · NIH-10804993 · Data updated 2026-11-12
This study is looking at how the body's stress response might help protect patients getting a special type of stem cell transplant from serious immune reactions, and it aims to find ways to prevent these reactions and improve treatment safety for people with blood cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Medical Center - Lexington, Ky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| NIH project number | 1I01BX006408-01 |
| Project ID | NIH-10804993 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing allogeneic hematopoietic cell transplantation for hematologic malignancies who may be at risk for cytokine release syndrome.
✕Less likely to help
Patients who are not undergoing allo-HCT or those without risk factors for cytokine release syndrome may not benefit from this research.
What this research studies
This research investigates the role of the adrenal stress response in protecting patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) from severe immune reactions known as cytokine release syndrome (CRS). The study aims to identify patients at high risk for CRS and explore preventive therapies by examining the production of glucocorticoids, which are crucial for managing immune responses. By using a specific mouse model, researchers will analyze how the absence of adrenal stress response affects the severity of CRS and overall patient outcomes. The goal is to enhance treatment safety and effectiveness for patients with hematologic malignancies.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for severe immune reactions in patients receiving life-saving cancer treatments.
How similar studies have gone: Previous research has shown that understanding the adrenal stress response can significantly impact treatment outcomes in similar patient populations, indicating a promising avenue for further exploration.
Where this research is happening
-
VA Medical Center - Lexington, Ky
Lexington, United States Active
Researchers
- Principal investigator: Li, Xiang-an — VA Medical Center - Lexington, Ky
- Study coordinator: Li, Xiang-an
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.