Understanding how adrenal glands develop and function in health and disease
Rosettes in Adrenal Development, Maintenance and Disease
This study is looking at how certain tiny structures in the adrenal glands help produce a hormone called aldosterone, which is important for blood pressure, and it aims to understand how problems with these structures might lead to high blood pressure issues, so that we can find better ways to treat adrenal diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10883000 on NIH RePORTER |
What this research studies
This research investigates the cellular and molecular mechanisms behind the development and maintenance of the adrenal cortex, particularly focusing on how certain structures called zG-rosettes influence aldosterone production. By using a specific mouse model, the study aims to uncover how disruptions in these processes can lead to conditions like primary aldosteronism, a common cause of high blood pressure. The research will explore the signaling pathways involved in the formation and resolution of these rosettes, which are crucial for normal adrenal function. Patients may benefit from insights gained into how adrenal diseases develop and how they might be treated.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with primary aldosteronism or other adrenal gland disorders.
Not a fit: Patients with adrenal conditions unrelated to aldosterone production may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for adrenal-related diseases, particularly those affecting hormone production.
How similar studies have performed: Other research has shown promising results in understanding adrenal gland function and related diseases, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Breault, David T — Boston Children's Hospital
- Study coordinator: Breault, David T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.