Understanding how ADP-ribosylation affects the immune response
Determining mechanisms of innate immune modulation by ADP-ribosylation
This study is looking at how a process called ADP-ribosylation can help our bodies fight off viruses, like coronaviruses, and aims to find ways to improve treatments for viral infections that could benefit patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Lawrence NIH-funded |
| Lab location | 1 site (Lawrence, United States) |
| Project ID | NIH-10918066 on NIH RePORTER |
What this research studies
This research investigates the role of ADP-ribosylation, a process that modifies proteins and influences various biological functions, including responses to cancer and infectious diseases. The study focuses on how this modification can enhance the body's antiviral response, particularly against viruses like coronaviruses. By using specific cell culture models and mutant viruses, researchers aim to uncover the mechanisms by which ADP-ribosylation can inhibit virus replication and promote immune responses. Patients may benefit from insights gained into how to better combat viral infections and improve treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with viral infections or those at risk of developing complications from such infections.
Not a fit: Patients with non-viral related conditions or those not affected by immune modulation may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for enhancing antiviral responses in patients.
How similar studies have performed: Other research has shown promising results in understanding the role of ADP-ribosylation in immune responses, suggesting that this approach may lead to significant advancements.
Where this research is happening
Lawrence, United States
- University of Kansas Lawrence — Lawrence, United States (Active)
Researchers
- Principal investigator: Fehr, Anthony R — University of Kansas Lawrence
- Study coordinator: Fehr, Anthony R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.