Understanding how ADP-ribosylation affects cell signaling
Chemistry and Biology of ADP-Ribosylation-Dependent Signaling
This study is exploring how a special process called ADP-ribosylation affects how our cells communicate, which could help us understand certain diseases better and find new ways to treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10875518 on NIH RePORTER |
What this research studies
This research investigates the process of ADP-ribosylation, a modification of proteins that plays a crucial role in cell signaling and communication. By studying the proteins involved in adding, reading, and removing ADP-ribose units, the research aims to uncover how these interactions influence various physiological and disease processes. The project will develop new tools to map these interactions more clearly, which could lead to a better understanding of their roles in human health. Patients may benefit from insights gained into how ADP-ribosylation affects diseases and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cellular signaling abnormalities or diseases where ADP-ribosylation plays a role.
Not a fit: Patients with conditions unrelated to cellular signaling or ADP-ribosylation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to ADP-ribosylation dysfunction.
How similar studies have performed: While the specific approach of mapping ADP-ribosylation interactions is novel, related research has shown promise in understanding protein modifications and their implications in disease.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Zhang, Yong — University of Southern California
- Study coordinator: Zhang, Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.