Understanding how adolescent alcohol use affects brain circuits
Official title: 7/8 NADIA U01 Recovery of Adolescent Alcohol Disruption of Basal Forebrain-Cortical Projection Circuits
Funded at State University of Ny,binghamton · NIH-11146077 · Data updated 2026-11-12
This study looks at how drinking a lot of alcohol during the teenage years can change the way the brain works and connects, and it’s trying to find out if things like exercise can help improve brain health for those affected.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of Ny,binghamton NIH-funded |
| Lab location | 1 site (Binghamton, United States) |
| Project start | September 1, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $151,199 |
| NIH project number | 3U01AA028710-05S1 |
| Project ID | NIH-11146077 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents aged 12-20 who have a history of heavy alcohol consumption.
✕Less likely to help
Patients who have not engaged in significant alcohol use or who are outside the adolescent age range may not benefit from this research.
What this research studies
This research investigates the long-term effects of heavy alcohol consumption during adolescence on brain structure and function. It focuses on how binge drinking alters the connectivity of brain circuits that are crucial for cognitive functions. The study uses animal models to explore the mechanisms behind these changes and examines potential recovery strategies, such as exercise, to reverse the negative impacts on brain health. By understanding these processes, the research aims to identify ways to support cognitive recovery in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that help restore cognitive function in adolescents who have experienced alcohol-related brain changes.
How similar studies have gone: Previous research has shown that interventions like exercise can positively influence brain recovery in similar contexts, suggesting a promising avenue for this study.
Where this research is happening
-
State University of Ny,binghamton
Binghamton, United States Active
Researchers
- Principal investigator: Savage, Lisa M — State University of Ny,binghamton
- Study coordinator: Savage, Lisa M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.