Understanding how ADH5 affects fat tissue metabolism
Role of ADH5 in the Regulation of Brown Adipose Tissue Metabolic Homeostasis
This study is looking at how a protein called ADH5 affects fat tissue in our bodies, especially when it comes to managing weight and dealing with stress from overeating, to help find new ways to improve health for people struggling with obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10885080 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called ADH5 in regulating the metabolism of brown adipose tissue (BAT), which is important for energy balance and responding to stress from overeating. The study aims to understand how obesity disrupts the normal function of ADH5, leading to inflammation and metabolic issues in fat tissue. By using animal models, the researchers will explore the relationship between ADH5, inflammation, and metabolic health, potentially identifying new targets for treatment. Patients may benefit from insights gained about how to improve metabolic health and manage obesity-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity or metabolic disorders related to fat tissue dysfunction.
Not a fit: Patients who are not affected by obesity or metabolic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating obesity and its associated metabolic disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of metabolic proteins in fat tissue, suggesting that this approach could yield valuable insights.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Yang, Ling — University of Iowa
- Study coordinator: Yang, Ling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.