Understanding how adenosine affects brain signaling
Multiplexed neurochemical methods to understand adenosine neuromodulation
This study is looking at how a brain chemical called adenosine affects other important chemicals in the brain, which could help us find new ways to treat neurological conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11049112 on NIH RePORTER |
What this research studies
This research investigates the role of adenosine, a neuromodulator, in brain signaling and its potential therapeutic applications. The team is developing advanced analytical tools that can measure multiple neurochemicals at once with high precision. By combining fast-scan cyclic voltammetry with genetically-encoded sensors, they aim to explore how adenosine influences neurotransmitters like dopamine and glutamate in real-time. This could lead to a better understanding of brain function and new treatment strategies for neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that may involve adenosine signaling, such as those recovering from a stroke.
Not a fit: Patients with conditions unrelated to neurotransmitter signaling or those not experiencing neurological issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for conditions related to neurotransmitter imbalances, such as stroke or brain trauma.
How similar studies have performed: Other research has shown promise in using similar multiplexed approaches to study neurochemical interactions, indicating potential for success in this area.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Venton, B. Jill — University of Virginia
- Study coordinator: Venton, B. Jill
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.