Understanding how acute pancreatitis can lead to type 1 diabetes
Official title: Type 1 Diabetes in Acute Pancreatitis Consortium, Pacific Northwest Clinical Center: Immune Pathogenesis of Post-Pancreatitis T1D
Funded at Benaroya Research Inst at Virginia Mason · NIH-10897973 · Data updated 2026-11-12
This study is looking at how having acute pancreatitis might lead to type 1 diabetes, and it's for people who have had pancreatitis; researchers will track their health over time to see if diabetes develops and how the immune system plays a role.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 16, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $215,625 |
| NIH project number | 5U01DK127404-05 |
| Project ID | NIH-10897973 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently suffered from acute pancreatitis and are at risk of developing type 1 diabetes.
✕Less likely to help
Patients who have not experienced acute pancreatitis or those with pre-existing type 1 diabetes may not benefit from this research.
What this research studies
This research investigates the connection between acute pancreatitis and the development of autoimmune diabetes, specifically type 1 diabetes. By analyzing a large patient population from Virginia Mason Medical Center, the study aims to uncover the incidence, clinical progression, and underlying mechanisms that lead to diabetes following pancreatitis. The research employs both clinical data and biological models to explore how immune responses may contribute to this condition. Patients will be monitored for the development of diabetes and the presence of autoantibodies over time.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for type 1 diabetes in patients who have experienced acute pancreatitis.
How similar studies have gone: Previous research has indicated a significant link between acute pancreatitis and the development of diabetes, but this study aims to provide novel insights into the mechanisms involved.
Where this research is happening
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Benaroya Research Inst at Virginia Mason
Seattle, United States Active
Researchers
- Principal investigator: Greenbaum, Carla J — Benaroya Research Inst at Virginia Mason
- Study coordinator: Greenbaum, Carla J
Related research
Other NIH-funded projects on the same topics.
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Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
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Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
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Type 1 Diabetes in Acute Pancreatitis in Diabetes Patients at Stanford
A Stanford-led project helps people with brittle type 1 diabetes who also experience pancreatitis by following them in a long-term study to understand how acute pancreatitis affects diabetes.
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Type 1 Diabetes after Acute Pancreatitis: Immune Clues from the Pacific Northwest
A multi-center study follows adults after an acute pancreatitis episode to understand how some develop Type 1 diabetes and what immune factors are involved.
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Diabetes After Acute Pancreatitis: Understanding Progression and Genetics at Cedars-Sinai
This grant supports Cedars-Sinai’s clinical center as part of a national effort to study why some adults develop brittle type 1 diabetes after an acute pancreatitis episode and how genes influence this risk.
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Understanding how acute pancreatitis may lead to type 1 diabetes
This study is looking at how having acute pancreatitis might lead to type 1 diabetes, and it aims to find early warning signs and risk factors to help identify people who could be at risk for developing diabetes after pancreatitis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.