Understanding how acute myeloid leukemia affects immune cell function
Dysregulation of Innate Lymphoid Immunity in Acute Myeloid Leukemia
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10900589
This study is looking at how acute myeloid leukemia affects the ability of important immune cells called natural killer (NK) cells to fight tumors, with the goal of finding ways to help these cells work better for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10900589 on ClinicalTrials.gov |
What this research studies
This research investigates how acute myeloid leukemia (AML) disrupts the function of innate immune cells, particularly natural killer (NK) cells, which are crucial for fighting tumors. The study aims to uncover the mechanisms behind the reduced effectiveness of these immune cells in AML patients, focusing on the development of NK cells from their precursors. By examining how AML alters the lineage of these immune cells, the research seeks to identify potential therapeutic targets that could restore immune function and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia who may benefit from enhanced immune therapies.
Not a fit: Patients with other types of leukemia or those who do not have acute myeloid leukemia may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response in AML patients, potentially improving survival rates.
How similar studies have performed: Previous research has shown promising results in enhancing immune responses in cancer patients, suggesting that this approach may lead to significant advancements in AML treatment.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUNDY-BOSSE, BETHANY — OHIO STATE UNIVERSITY
- Study coordinator: MUNDY-BOSSE, BETHANY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.