Understanding how activated protein C can help fight infections and inflammation
Regulation of Protein C Pathways
This study is looking at how a special protein called activated protein C can help control inflammation and boost the immune system during infections like COVID-19, with the hope of finding new treatments that could improve recovery for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11075261 on NIH RePORTER |
What this research studies
This research investigates the role of activated protein C (APC) in regulating inflammation and immune responses, particularly in the context of infections like COVID-19. By studying various engineered forms of APC, the research aims to identify how these proteins interact with different cell receptors to enhance the body's defense mechanisms. The approach includes extensive laboratory experiments using animal models to explore the therapeutic potential of APC in reducing complications from infections and improving patient outcomes. Patients may benefit from insights gained into how APC can be used to develop targeted treatments for severe inflammatory responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with severe COVID-19 or other conditions characterized by excessive inflammation.
Not a fit: Patients with mild infections or those not experiencing significant inflammatory responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve survival and recovery rates for patients suffering from severe infections and inflammatory conditions.
How similar studies have performed: Previous research has shown promising results with activated protein C in various preclinical models, indicating potential for success in clinical applications.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Mosnier, Laurent Olivier — Scripps Research Institute, the
- Study coordinator: Mosnier, Laurent Olivier
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.