Understanding How Actin Works in Our Cells
Structural-Functional Mechanisms Controlling Actin Filament Barbed and Pointed End Dynamics
This research explores how a key protein called actin functions within our cells, which is important for many body processes and diseases like cancer and heart conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11137690 on NIH RePORTER |
What this research studies
Actin is a very common protein found in all our cells, playing a vital role in how cells move, muscles contract, and even how diseases like cancer spread. It exists in two forms, and this project focuses on how these forms change and interact, especially at the ends of its filament structures. Our cells carefully control these changes using other proteins and energy, but we don't fully understand how this control works. By studying these basic processes, we hope to learn more about how actin contributes to both healthy cell function and various diseases.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation but aims to benefit individuals affected by diseases linked to cell function, such as cancer or heart conditions, through future discoveries.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not receive direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this fundamental understanding of actin could lead to new ways to address conditions like cancer, muscle disorders, and heart diseases in the future.
How similar studies have performed: While actin's general role is known, the specific structural and functional mechanisms controlling its filament end dynamics are poorly understood, making this a novel and foundational area of inquiry.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Dominguez, Roberto — University of Pennsylvania
- Study coordinator: Dominguez, Roberto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.