Understanding how actin structures in cells are formed and regulated
Mechanisms controlling cellular actin dynamics and cytoskeletal crosstalk
['FUNDING_OTHER'] · BRANDEIS UNIVERSITY · NIH-11011530
This study looks at how tiny structures in our cells, called actin, come together and break apart, which is important for how cells move and hold their shape, and it aims to help us understand these processes better to find new ways to treat diseases caused by cell problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRANDEIS UNIVERSITY (nih funded) |
| Locations | 1 site (WALTHAM, UNITED STATES) |
| Trial ID | NIH-11011530 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that control the assembly and disassembly of actin structures within cells, which are crucial for various cellular functions such as movement, adhesion, and shape. By using advanced microscopy techniques, researchers can observe how different proteins work together in real-time to manage actin dynamics. The study aims to uncover the complex interactions between actin and other components of the cytoskeleton, providing insights that could lead to new therapeutic strategies for diseases related to cellular dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, amyotrophic lateral sclerosis, or other conditions related to cytoskeletal dysfunction.
Not a fit: Patients with conditions unrelated to actin dynamics or cytoskeletal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions like Alzheimer's disease and amyotrophic lateral sclerosis by targeting the underlying cellular mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding actin dynamics, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
WALTHAM, UNITED STATES
- BRANDEIS UNIVERSITY — WALTHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOODE, BRUCE L — BRANDEIS UNIVERSITY
- Study coordinator: GOODE, BRUCE L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease