Understanding how actin helps chromosomes separate in eggs and embryos
Actin-based mechanisms of chromosome segregation in mammalian oocytes and embryos
This study is looking at how tiny structures in cells help make sure chromosomes are evenly divided during cell division, which is really important for healthy pregnancies and preventing issues like miscarriages or developmental problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10916284 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind chromosome segregation in mammalian oocytes and embryos, focusing on the role of actin filaments. By using advanced microscopy techniques, the study aims to uncover how spindle F-actin contributes to the accurate distribution of chromosomes during cell division. This is particularly important as errors in chromosome segregation can lead to aneuploidy, a significant cause of miscarriages and developmental disorders. The research seeks to identify the assembly and function of spindle F-actin at the chromosome-microtubule interface, which could lead to new insights into reproductive health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing recurrent miscarriages or infertility due to chromosomal abnormalities.
Not a fit: Patients who do not have a history of chromosomal issues or reproductive challenges may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for conditions related to chromosome segregation errors, ultimately enhancing reproductive outcomes.
How similar studies have performed: Other research has shown promising results in understanding chromosome segregation mechanisms, but the specific role of spindle F-actin in this context is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Mogessie, Binyam — Yale University
- Study coordinator: Mogessie, Binyam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.