Understanding how actin filaments work in cell processes
Actin filament mechanics and branched network turnover
This study is looking at how tiny structures in our cells, called actin filaments, work together to help cells move and divide, and it’s for anyone interested in understanding how our cells stay healthy and function properly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11089902 on NIH RePORTER |
What this research studies
This research investigates the mechanics of actin filaments, which are crucial for various cellular functions such as movement, nutrient uptake, and cell division. By combining biochemical and biophysical experiments, the study aims to create predictive models that explain how these filaments assemble, remodel, and recycle within cells. The research will also explore how specific proteins influence the activity of the Arp2/3 complex, which is essential for forming branched networks of actin filaments. This work could enhance our understanding of fundamental cellular processes and their regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve cellular dysfunction, such as cancer or certain genetic disorders affecting cell motility.
Not a fit: Patients with conditions unrelated to cellular processes or actin filament dynamics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular functions that may inform treatments for diseases related to cell movement and division.
How similar studies have performed: Other research has shown success in understanding actin filament dynamics, but this specific approach to modeling their mechanics is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: De la Cruz, Enrique M — Yale University
- Study coordinator: De la Cruz, Enrique M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.