Understanding how actin filaments shape cells and influence development
Actin cytoskeleton from nucleus to organism
This study looks at how tiny structures in cells, called actin filaments, help shape and support cells, using fruit fly embryos to learn how genes and signals control these structures, which could help us understand how cells work together to keep us healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project ID | NIH-10895303 on NIH RePORTER |
What this research studies
This research investigates the role of actin filaments in determining cell shape and function, focusing on how gene expression and signaling pathways control actin remodeling. By studying Drosophila embryos, the researchers aim to connect the molecular mechanisms of actin dynamics with the overall development of tissues. The approach combines advanced genetic techniques with live-cell imaging to observe the behavior of actin and its regulatory proteins in real-time. This comprehensive understanding could reveal critical insights into how cellular processes affect organismal health and development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital abnormalities or conditions linked to actin dysfunction.
Not a fit: Patients with conditions unrelated to actin dynamics or those who do not have congenital abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing congenital abnormalities and improving developmental outcomes.
How similar studies have performed: Other research has shown promising results in understanding actin dynamics, but this approach aims to provide a more integrated view, making it a novel investigation.
Where this research is happening
Champaign, United States
- University of Illinois at Urbana-Champaign — Champaign, United States (Active)
Researchers
- Principal investigator: Sokac, Anna — University of Illinois at Urbana-Champaign
- Study coordinator: Sokac, Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.