Understanding how actin filaments help maintain cell and organelle health
Official title: Elucidating the roles for discrete actin filaments in maintenance of organelle and cellular homeostasis
Funded at Thomas Jefferson University · NIH-10911259 · Data updated 2026-11-12
This study is looking at how tiny structures in our cells, called actin filaments, help keep important parts of the cell, like the endoplasmic reticulum and mitochondria, working well, which could lead to better understanding of health and diseases related to these cell parts.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 21, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $390,000 |
| NIH project number | 5R35GM150811-02 |
| Project ID | NIH-10911259 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions related to mitochondrial or endoplasmic reticulum dysfunction.
✕Less likely to help
Patients with conditions unrelated to cellular organelle health may not receive any benefit from this research.
What this research studies
This research investigates the roles of actin filaments in maintaining the health and function of cellular organelles, particularly the endoplasmic reticulum and mitochondria. By examining how different pools of actin filaments interact with these organelles, the research aims to uncover the mechanisms that regulate their dynamics and communication. The approach involves studying the assembly of actin structures around these organelles and how they influence cellular processes. Patients may benefit from insights gained about cellular health and disease mechanisms related to organelle dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to organelle dysfunction.
How similar studies have gone: While the role of actin filaments in organelle dynamics is less studied, there is potential for success based on previous findings in related areas of cytoskeletal research.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Chakrabarti, Rajarshi — Thomas Jefferson University
- Study coordinator: Chakrabarti, Rajarshi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.