Understanding how actin filaments help maintain cell and organelle health
Elucidating the roles for discrete actin filaments in maintenance of organelle and cellular homeostasis
This study is looking at how tiny structures in our cells, called actin filaments, help keep important parts of the cell, like the endoplasmic reticulum and mitochondria, working well, which could lead to better understanding of health and diseases related to these cell parts.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10911259 on NIH RePORTER |
What this research studies
This research investigates the roles of actin filaments in maintaining the health and function of cellular organelles, particularly the endoplasmic reticulum and mitochondria. By examining how different pools of actin filaments interact with these organelles, the research aims to uncover the mechanisms that regulate their dynamics and communication. The approach involves studying the assembly of actin structures around these organelles and how they influence cellular processes. Patients may benefit from insights gained about cellular health and disease mechanisms related to organelle dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to mitochondrial or endoplasmic reticulum dysfunction.
Not a fit: Patients with conditions unrelated to cellular organelle health may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to organelle dysfunction.
How similar studies have performed: While the role of actin filaments in organelle dynamics is less studied, there is potential for success based on previous findings in related areas of cytoskeletal research.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Chakrabarti, Rajarshi — Thomas Jefferson University
- Study coordinator: Chakrabarti, Rajarshi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.