Understanding how actin and gene regulatory complexes communicate
Mechanism and effects of communication between actin and gene regulatory complexes
This study looks at how a part of our cells called actin interacts with the systems that control our genes, hoping to find out more about diseases that affect our vision and nervous system, which could help patients understand the causes of their conditions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-11084941 on NIH RePORTER |
What this research studies
This research investigates the interactions between actin, a key component of the cell's structure, and gene regulatory complexes that control gene expression. By examining how these two systems communicate, the study aims to uncover mechanisms that could explain certain diseases, particularly those affecting the nervous system and vision. The research employs advanced techniques to analyze the behavior of these complexes in cells, focusing on mutations that lead to conditions like blindness and nervous system degeneration. Patients may benefit from insights gained about the underlying causes of these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations linked to nervous system degeneration or blindness.
Not a fit: Patients with conditions unrelated to actin dynamics or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating blindness and neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of cytoskeletal dynamics in gene expression, suggesting that this approach could yield valuable insights.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Mohan, Ryan David — Wayne State University
- Study coordinator: Mohan, Ryan David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.